A REVIEW ON LUPEOL- BENEFICIAL HEALTH ASPETS OF POTENT NATURAL PHYTOSTEROL AND TRITERPENE
Nashra
M.Pharm Research Scholar, Department of Pharmacology, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot no-19, Knowledge Park-II, Greater Noida, Uttar Pradesh-201306, nashrashafiq007@gmail.com
Saumya Das
PHD, Faculty of Pharmacy, Associate Professor, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot no-19, Knowledge Park-II, Greater Noida, Uttar Pradesh-201306
Pratishttha Bharadwaj
M.Pharm Research Scholar, Department of Pharmacology, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot no-19, Knowledge Park-II, Greater Noida, Uttar Pradesh-201306
Himanshu Singh
M.Pharm Research Scholar, Department of Pharmacology, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot no-19, Knowledge Park-II, Greater Noida, Uttar Pradesh-201306
Manas Kumar Das
Director at Orlean College of Pharmacy (Department of Pharmacology), Greater Noida, Uttar Pradesh-201308
Abstract
Conventional frameworks of medication have been dynamically acquiring interest and acknowledgment everywhere in the world, even among the experts of current medication. Several clinically useful medications have come from natural substances like herbal therapies used throughout ancient traditional medicines since they have minimal side effects, are generally inexpensive, but are supposed to be beneficial. Natural triterpenoids, further recognized as phytosterols, are gaining popularity due to their broad range of pharmacological processes. A nutritional triterpene called lupeol would be one of those operatives that have attracted widespread focus from healthcare experts, pharmaceutical advertisers, and experts. Lupeol a triterpene otherwise called Fagarsterol found in white cabbage, green pepper, strawberry, olive, mangoes, and grapes was accounted to have gainful impacts as a restorative and preventive specialist for several problems. In the last 15 years, scientists have worked tirelessly to create such a marvellous compound for its clinical use in the cure of different illnesses. These investigations promote give an understanding of the system of activity of lupeol and propose that it is a multi-target specialist with tremendous anti-inflammatory potential by focusing on key sub-atomic pathways which include nuclear factor kappa-B (NFκB), Cflip, Fas, Kras, phosphatidylinositol-3-kinase (PI3K)/Akt and Wnt/β-catenin in an assortment of cells. Much more in-vitro as well as preclinical animal research indicates that somehow lupeol might also have anti-inflammatory, anti-microbial, anti-protozoal, anti-proliferative, anti-invasive, anti-angiogenic, or cholesterol-lowering properties. Several research studies have found lupeol's anti-inflammatory activity that inhibits neuroinflammation throughout the cerebellum or triggers neuroprotection by modulating p-38 pathways.
Keywords:
Lupeol, Triterpenoids, Phytosterol, Anti-inflammatory, Triterpenes.Full Text:
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