The Effect of Syzygiumpolyanthum Extract in Lipid Profile of Hypercholesterolemic Animal Model

Rachmat Hidayat, Patricia Wulandari


Syzygiumpolyanthum (Sp) extract has the potential as an antioxidant, anti-inflammatory, and antidiabetic activity due to the presence of flavonoids. This study aimed to explore the anti hypercholesterolemia potential of Sp leaves extract in rats. Thirty male Wistar rats, ranging from 200-250 grams body weight, were randomly divided into five groups (group 1: normal group; group 2: hypercholesterol rats without treatment; group 3: hypercholesterol rats with simvastatin treatment; group 4: hypercholesterol rat with Sp extract 100 mg/kg BW; group 5: hypercholesterol rats with Sp extract 200mg/kg BW). The induction of hypercholesterolemia rats was done by giving high cholesterol diet (HCD). This study showed that Sp extract and simvastatin treatment have improved HDL levels and normalized the elevated levels of cholesterol and LDL. The antioxidant components were decreased in all hyperlipidemic groups compared to group 1. Sp extract was proven to improve SOD level and catalase as an indication of improvement in antioxidant potential. Sp extract treatment has improved the levels of SOD and catalase as an indication of improvement in the antioxidant potential. In conclusion, our results show that Sp extract can improve the hypercholesterolemic condition through ameliorating dyslipidemia, reducing HMG-CoA content, binding of bile acids, and improving the antioxidant status.




Keywords: antioxidants, hypercholesterolemia, catalase, Syzygium, hyperlipidemias.




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