Treadmill and Ergo cycle Exercises Increase Insulin-Like Growth Factor-1 Levels in Obese Female

Adi Pranoto, Zakaria Sendy Wardana, Misbakhul Munir, Hayuris Kinandita, Desiana Merawati, Sugiharto, Purwo Sri Rejeki


Obesity increases the risk incidence of metabolic disorders, including insulin resistance, causing an increase in blood glucose. Physical exercises, mediated by Insulin-Like Growth Factor-1 (IGF-1), contribute to improving insulin sensitivity and lowering blood glucose. IGF-1 increases insulin sensitivity and maintains glucose homeostasis by activating the Phosphoinositide 3-Kinase (PI3K) pathway and translocation of Glucose Transporter Protein-4 (GLUT-4). The purpose of the study was to analyze the effect of a moderate-intensity treadmill and ergo cycle exercises on the increasing IGF-1 levels in the obese female. This research was a true experimental study with the randomized pretest-posttest control group design. Subjects were 27 obese females aged 18-22. Subjects were randomly divided into three groups, that is CONT (n=9, group without intervention), ERGO-Exercise (n=9, Ergocycle Exercise), and TREAD-Exercise (n=9, Treadmill Exercise). Interventions for TREAD-Exercise and ERGO-Exercise were conducted continuously for 30 minutes, from 07.00-10.00 a.m. Blood samples were taken pre-exercise and 15 minutes post-exercise. IGF-1 levels were examined by the Enzyme-Linked Immunosorbent Assay (ELISA) method. Data were analyzed using ANOVA test and LSD post hoc test using Statistic Package for Social Science (SPSS). The research results showed that one session of a moderate-intensity treadmill and ergo cycle exercise for 30 minutes increases IGF-1 levels compared to the control. It is necessary to conduct advanced research to analyze chronic intervention (training) for increasing IGF-1 levels in obese females.



Keywords: IGF-1 levels, treadmill, ergo cycle, obese female




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