ANALYSIS OF SOME CAUSAL FACTORS PROVOKING A SEVERE COURSE OF BEHCET'S DISEASE IN ADOLESCENT PATIENTS

Munisa A. Mirsaidova Republican Specialized Scientific and Practical Medical Center for Dermatovenerology and Cosmetology, Tashkent, Uzbekistan, munisa876@mail.ru
Delya F. Porsokhonova Republican Specialized Scientific and Practical Medical Center for Dermatovenerology and Cosmetology, Tashkent, Uzbekistan, delya.porsokhonova@mail.ru
Yulduz N. Radjabova Republican Specialized Scientific and Practical Medical Center for Dermatovenerology and Cosmetology, Tashkent, Uzbekistan, Corresponding Author Email ID: dr.radjabova@gmail.com
Khilola Kh Fayzieva Republican Specialized Scientific and Practical Medical Center for Dermatovenerology and Cosmetology Tashkent, Uzbekistan, xfx.cosmetology1993@gmail.com

Abstract

Aim: The aim of our study was to conduct a comparative analysis of the factors leading to a further aggravation of the course of Behcet's disease in adolescent patients. The authors examined and treated 8 persons of adolescent age diagnosed with Behcet's disease. Simultaneously with clinical and anamnestic observation, a thorough examination of the mucous membranes of the urogenital tract was carried out for the presence of urogenital infections of a bacterial-viral nature, a study of autoimmune antibodies (Anti-double-stranded DNA, IgG and Anti-single-stranded DNA, IgG) in the blood serum of patients, consultations of related specialists. It was found that among the features of the clinical course of Behcet's disease in adolescents, the prevailing symptoms are aphthous stomatitis, erosive and ulcerative lesions of the oral mucosa and eye lesions. Among infections of the genital mucosa, herpesvirus, papillomavirus, ureaplasma and candida infections are detected with an increased frequency. A 1.5-fold increase in the content of autoimmune antibodies (Anti-double-stranded DNA, IgG and Anti-single-stranded DNA, IgG) was noted, which indicates the beginning of the formation of an autoimmune component in the development of the disease. Connection of appropriate antiviral and antibacterial drugs to therapy significantly accelerates the recovery time and lengthens the recurrence intervals.

Keywords:

Behcet's disease, causal factors, adolescent patients.


Full Text:

PDF


References



1. Davatchi F, Shahram F, Chams-Davatchi C, et al. Behcet’s disease: from East to West. Clin Rheumatol. 2010;29(8):823–833. doi: 10.1007/s10067-010-1430-6. 2. Karincaoglu Y, Borlu M, Toker SC, et al. Demographic and clinical properties of juvenile-onset Behcet’s disease: A controlled multicenter study. J Am Acad Dermatol. 2008;58(4):579–584. doi: 10.1016/j.jaad.2007.10.452. 3.Davatchi F, Sadeghi Abdollahi B, Chams-Davatchi C, et al. The saga of diagnostic/classification criteria in Behcet’s disease. Int J Rheum Dis. 2015;18(6):594–605. doi: 10.1111/1756- 185X.12520. 4. Direskeneli H. Autoimmunity vs autoinflammation in Behcet’s disease: do we oversimplify a complex disorder? Rheumatology (Oxford). 2006;45(12):1461–1465. doi: 10.1093/rheumatology/kel329. 5, Yazici H. The place of Behcet’s syndrome among the autoimmune diseases. Int Rev Immunol. 1997;14(1):1–10. doi: 10.3109/08830189709116840. 6. Mendoza-Pinto C, Garcia-Carrasco M, Jimenez-Hernandez M, et al. Etiopathogenesis of Behcet’s disease. Autoimmun Rev. 2010; 9(4):241–245. doi: 10.1016/j.autrev.2009.10.005. 7. Prenzel F, Uhlig HH. Frequency of indeterminate colitis in children and adults with IBD — a metaanalysis. J Crohns Colitis. 2009;3(4):277–281. doi: 10.1016/j.crohns.2009.07.001. 8. Alekberova Z. Behcet’s disease in children. Current pediatrics. 2009;8(6):64–70. 9. de Albuquerque PR, Terreri MT, Len CA, Hilario MO. [Behcet’s disease in childhood]. J Pediatr (Rio J). 2002;78(2):128–132. doi: 10.2223/jped.827. 10. Kuz’mina NN, Salugina SO, Fedorova ES. Autoinflammatory diseases and syndromes in children. Study guide. Moscow; 2012. p. 63–64. 11. Gul A. Behcet’s disease as an autoinflammatory disorder. Curr Drug Targets Inflamm Allergy. 2005;4(1):81–83.

Refbacks

  • There are currently no refbacks.