EFFICIENCY OF A NEW INFUSION DRUG WITH ANTIOXIDANT AND ANTIHYPOXANT EFFECT IN ACUTE BLOOD LOSS

Jamoliddin Dj. Khujahmedov Doctor of Philosophy of Medical Sciences (PhD), hematologist, director of Molecular Genetic Laboratory "GenoTexnologiya", Uzbekistan, Tashkent, Email: 5420256@rambler.ru
Larisa I. Shevchenko PhD in Biological Sciences, pharmacist, «Department of Molecular Medicine and Cell Technologies», Republican specialized scientific-practical medical center of Hematology (RSSPMCH), Uzbekistan, Tashkent, Email: moriturus1958@mail.ru
Khamid Ya. Karimov Doctor of Medical Sciences (DSc), Professor, Head of «Department of Molecular Medicine and Cell Technologies», Republican specialized scientific-practical medical center of Hematology (RSSPMCH) MoH RUz, Uzbekistan, Tashkent, Email: info.niigem@minzdrav.uz
Timur R. Alimov Doctor of Philosophy of Medical Sciences (PhD), Department of Molecular Medicine and Cell Technology, hematologist, Republican specialized scientific-practical medical center of Hematology (RSSPMCH) MoH RUz , Uzbekistan, Tashkent, 100097, Chilonzor distr., Bunyodkor str.42-а., Email: alteam2201@gmail.com, Orcid.org/0000-0003-4432-5694

Abstract

In the Republican Specialized Scientific and Practical Medical Center of Hematology (RSNPMTSG) of the Ministry of Health of the Republic of Uzbekistan (formerly the Scientific Research Institute of Hematology and Blood Transfusion of the Ministry of Health of the Republic of Uzbekistan) together with the Institute of Chemistry of Plant Substances named after academician Yunusov S.Yu (ICPS) has developed a new infusion preparation of hemodynamic, antioxidant and antihypoxant action, containing a complex of polysaccharides and a metabolite of the Krebs cycle. The work aims to compare the hemodynamic and antioxidant properties of the drug "Rheoambrasol" in acute hemorrhage, with "Rheopolyglukin" widely used in medical practice. The work was performed on a model of acute blood loss in 40 rabbits. Hypoxia-inducible factor (HIF-1a), as well as hemodynamic parameters, as well as lipid peroxidation (LPO), and the state of the antioxidant system (AOS) were studied. The use of a new drug in blood loss leads to the restoration of hemodynamics, inhibition of lipid peroxidation (LPO), and stabilization of the antioxidant system (AOS).

Keywords:

polysaccharides, Krebs cycle metabolite, blood loss, Hypoxia-inducible factor (HIF-1α), lipid peroxidation (LPO), antioxidant system (AOS).


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References



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