MODERN PICOSECOND LASERS FOR PIGMENTATION TREATMENT

Ulugbek Yusupkhanovich Sabirov Republican Specialized Scientific and Practical Medical Center of Dermatovenerology and Cosmetology, Ministry of Health of Uzbekistan, Tashkent, Uzbekistan
Avaz Shavkatovich Inoyatov Republican Specialized Scientific and Practical Medical Center of Dermatovenerology and Cosmetology, Ministry of Health of Uzbekistan, Tashkent, Uzbekistan
Bobur Akbarovich Toirov Republican Specialized Scientific and Practical Medical Center of Dermatovenerology and Cosmetology, Ministry of Health of Uzbekistan, Tashkent, Uzbekistan
Nigora Bakhramovna Khodjaeva Republican Specialized Scientific and Practical Medical Center of Dermatovenerology and Cosmetology, Ministry of Health of Uzbekistan, Tashkent, Uzbekistan
Elena Vladimirovna Kalendareva Republican Specialized Scientific and Practical Medical Center of Dermatovenerology and Cosmetology, Ministry of Health of Uzbekistan, Tashkent, Uzbekistan
Marguba Ziyadullaevna Nazarova Republican Specialized Scientific and Practical Medical Center of Dermatovenerology and Cosmetology, Ministry of Health of Uzbekistan, Tashkent, Uzbekistan
Ilona Igorevna Nazarova Republican Specialized Scientific and Practical Medical Center of Dermatovenerology and Cosmetology, Ministry of Health of Uzbekistan, Tashkent, Uzbekistan
Elena Valerevna Ligay Republican Specialized Scientific and Practical Medical Center of Dermatovenerology and Cosmetology, Ministry of Health of Uzbekistan, Tashkent, Uzbekistan

Abstract

At the heart of the development of dermatoses accompanied by a violation of pigmentation is undoubtedly the process of melanogenesis, which is a very complex multistage and difficult-to-regulate. From a molecular genetic point of view, about 280 genes of various proteins, factors of cellular and intercellular interaction, regulating melanogenesis, have been found. Nevertheless, the scientific research of many scientists in recent years has made it possible to deeply advance in understanding the mechanisms of regulation of this process. In particular, the role of medium-wave ultraviolet radiation, predominantly spectrum B (UVB), on human skin, and the mechanisms of its biophotonics have been established. Ultraviolet B triggers cascades of reactions not only in melanocytes, but also in keratinocytes, which are predominantly more abundant in the epidermis and fibroblasts, which form the basis of dermal structures. Thus, these three groups of cells under the influence of excess UV radiation begin to stimulate the production and transport of melanin in the melanosomes into the keratinocyte cells in order to prevent damage to nuclear DNA. Melanin absorbs UV radiation very well and is a chromophore, thus protecting the skin from damage.

Keywords:

laser, melasma, chloasma, hyperpigmentation, picosecond laser (PSL), PicoWay, Zoom, Resolve.


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References



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