ROLE OF GENOTYPES OF STAPHYLOCOCCUS SPP. IN THE CLINICAL COURSE OF ALLERGIC DERMATOSES

Shakhnoza Zakirovna Mavlyanova Professor, DSc, Head of the Department of Dermatology, Republican Specialized Scientific and Practical Medical Center of Dermatovenereology and Cosmetology Ministry of Health Tashkent, Uzbekistan
Jovlon Bakhtiyorovich Mullakhanov PhD, Senior Researcher, Republican Specialized Scientific and Practical Medical Center of Dermatovenereology and Cosmetology, Ministry of Health, Tashkent, Uzbekistan
Sevara Rustamovna Muminova PhD, Head of the Department of Dermatocosmetology, Republican Specialized Scientific and Practical Medical Center of Dermatovenereology and Cosmetology, Ministry of Health Tashkent, Uzbekistan
Yulduz Askarovna Alimukhamedova PhD, Senior Researcher, Republican Specialized Scientific and Practical Medical Center of Dermatovenereology and Cosmetology, Ministry of Health, Tashkent, Uzbekistan
Nigora Yarkinbaevna Madrakhimova Epidemiologist of the Republican Specialized Scientific and Practical Medical Center of Dermatovenereology and Cosmetology, Ministry of Health, Tashkent, Uzbekistan
Barno Ulmasovna Nazarova Researcher of the Republican Specialized Scientific and Practical Medical Center for Dermatovenereology and Cosmetology, Ministry of Health, Tashkent, Uzbekistan

Abstract

The article provides data from molecular genetic studies to identify genotypes of staphylococci in patients with allergic skin diseases. Examined 312 patients with allergic dermatoses at the age from 7 to 67 years. Clinical-microbiological and molecular-genetic studies have shown that in patients with allergic skin diseases, genotypes of staphylococci are isolated in 44.5% of cases. Among them, methicillin-resistant staphylococcus aureus (MRSA) was detected in 58 out of 142 DNA samples, which accounted for 40.8% of cases. Whereas the genotypes of methicillin-sensitive staphylococcus (MSSA) were detected in 61 (42.9%) patients, and methicillin-resistant coagulonegative Staphylococcus spp (MRCoNS) - in 23, which amounted to 16.2% of cases, respectively.

Keywords:

allergic dermatoses, atopic dermatitis, allergodermatitis, clinical picture, severity, staphylococcus, staphylococcus genotypes, methicillin-resistant staphylococcus.


Full Text:

PDF


References



1. Bayazitova L.T. Virulent properties of staphylococcal skin microflora in atopic dermatitis: author. dis. Cand. honey. Sciences: 14.01.09 / Bayazitova Lira Tabrisovna. - Ufa, 2009 .-- 22 p.
2. Belousova T.A., Goryachkina M.A., Katranova A.G. Features of skin microbiocenosis in patients with allergic dermatoses: the problem of choosing external therapy. // Clinical Dermatology and Venereology. - No. 3. - 2013 - S. 13-19.
3. Gostev V.V., Sidorenko S.V. Bacterial biofilms and infections // Journal of Infectology. 2010. Vol. 2, No. 3. P. 4–15.
4. Elisyutina O.G., Fedenko E.S. The role of Staphylococcus aureus in the pathogenesis of atopic dermatitis
5. Kalyuzhka E.A. "Genetic risk factors for the development of allergic diseases in children" 2016 - vip. 1, volume 2 (127), pp. 16-20.
6. Kozlova N.S., Barantsevich N.E., Barantsevich E.P. Antibiotic resistance of causative agents of purulent septic infections in a multidisciplinary hospital // Problems of medical mycology. 2018.T 20.N 1.S. 40-48.
7. Mavlyanova Sh.Z. Atopic dermatitis. // Monograph. - Toshkent - 2014. –S. 163.
8. Methicillin-resistant Staphylococcus aureus: the problem of distribution in the world and in Russia. www.fesmu.ru.
9. Murashkin N.N., Gluzmin M.I., Bakulev A.L. The role of methicillin-resistant strains of Staphylococcus aureus in the pathogenesis of severe forms of atopic dermatitis in children // Bulletin of Dermatol. and venerol. 2012.Vol. 1.P. 68–76.
10. Mokronosova M.A., Maksimova A.E., Baturo A.P. et al. Influence of various methods of external therapy on the colonization of the skin by Staphylococcus aureus and the course of atopic dermatitis // Russian Allergological Journal. 2004. - No. 12. - S. 58-61.
11. Olisova O.Yu. Therapeutic skin care for atopic dermatitis. // Wedge. dermatology and venereology. - 2009. - No. 1. S. 54-57.
12. Tyurin Yu.A. The role of pathogenicity factors of Staphylococcus aureus in the development of atopic dermatitis / Yu. A. Tyurin, DA Dolbin // Zh. microbiol. 2008. - No. 4. - S. 105-110.
13. Hamaganova IV Pustular diseases, skin. Attending physician: 2006, No. 9, pp. 5-12.
14. Alsterholm M., Flytstrom I., Bergbrant I. M., Faergemann J. Fusidic acid-resistant Staphylococcus aureus in impetigo contagiosa and second infected atopic dermatitis. Acta Derm Venereol 2010; 90: 1: P. 52-57.
15. Baker B.S. The role of microorganisms in atopic dermatitis // ClinExp Immunol., 2006. - Vol. 144. - P. 1-9.
16. Biber, T. Atopic dermatitis: from the genes the scin lesions / T. Biber, A. Wollenberg // Allergy. 2000. - Vol. 55. - P. 205-213.
17. Brodská P, Panzner P, Pizinger K, Schmid-Grendelmeier P. IgE-mediated sensitization to malassezia in atopic dermatitis: more common in male patients and in head and neck type. Dermatitis. 2014; 25 (3): P. 120-126.
18. Clarke S.R. A of Staphylococcus aureus is a broad spectrum, iron-regulated adhesin / S. R. Clarke, M. D. Wiltshire, S. J. Foster // Molecular Microbiology. 2004. - Vol. 51, No. 5. - P. 1509-1519.
19. Salgado C.D. Community-acquired meticillin-resistant Staphylococcus aureus: A meta-analysis of prevalence and risk factors / C. D. Salgado, B. M. Farr, D. R. Galfee // Clin. Infect. Dis. 2003. - Vol. 36. - P. 131-139.
20. Spaulding A.R., Lin Y.C., Merriman J.A. et al. Immunity to Staphylococcus aureus secreted proteins protects rabbits from serious illnesses. Vaccine. 2012, 30 (34): 5099-5109.
21. Stevens DL, Herr D, Lampiris H et al; the Linezolid MRSA Study Group. Linezolid versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections. Clin Infect Dis 2002; 34: 1481-1490.
22. Zollner T. M., Wichelhaus T. A., Hartung A. et al. Colonization with superantigen producing Staphylococcus aureus associated with increased severity of atopic dermatitis // Clin. Exp. Allergy. 2000. - Vol. 30: - No. 7. - P. 994-1000.

Refbacks

  • There are currently no refbacks.