THE STATE OF ENDOTHELIAL FUNCTION IN PATIENTS WITH CHRONIC HEART FAILURE WITH VARIOUS MANIFESTATIONS OF THE METABOLIC SYNDROME
Atakhodjaeva Gulchekhra Abdunabievna
DSc, Associate Professor, Department of Internal Medicine, nephrology and hemodialysis Tashkent Pediatric, Medical Institute
DSc, Associate Professor, Department of Internal Medicine, nephrology and hemodialysis Tashkent Pediatric, Medical Institute
Aripova Jamilya Shukhratovna
PhD, Associate Professor, Department of Internal Medicine, Nephrology and Hemodialysis Tashkent Pediatric, Medical Institute, Tashkent Pediatric Medical Institute, Uzbekistan
PhD, Associate Professor, Department of Internal Medicine, Nephrology and Hemodialysis Tashkent Pediatric, Medical Institute, Tashkent Pediatric Medical Institute, Uzbekistan
Abstract
: The leading role in the pathogenesis of CHF is given to endothelial dysfunction. The development of severe endothelial dysfunction in CHF is due to hyperactivation of the SAS and RAAS, hyperproduction of pro-inflammatory cytokines. It consists in reducing the production of vasodilators and increasing the synthesis of vasoconstrictor substances. The main factors that disrupt EF in CHF are myocardial dysfunction, which contributes to a decrease in the hemodynamic shear stress force, neurohumoral balance, hypoxia, chronic inflammation, and intoxication [1, 4, 12, 15]. It is also necessary to note the factors that exacerbate the processes of myocardial and vascular remodeling in CHF, of which the MS components (IR, AH, DM, DLP, HTG) are significant [2,3]. Vessel remodeling in MS, on the one hand, is a consequence of the effects of IR and compensatory hyperglycemia, as well as elevated blood pressure on the vascular wall, on the other hand, it leads to the development and progression of IR and AH on its own [3, 7]. This condition is characterized by a decrease in endothelium-dependent vasodilation (EDVD) and increased adhesiveness of the endothelial lining [2, 3, 4, 7, 8].
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