THE ROLE OF CHANGES IN THE CONTENT OF PROTEASES AND PROTEASE INHIBITORS IN CHRONIC PURULENT WOUNDS

The work studied the features of changes in the content of proteases and protease inhibitors in chronic purulent wounds. It was concluded that in postoperative wounds, the indicators of general proteolytic activity and antiproteolytic activity do not differ significantly; there is a balance between proteases and protease inhibitors, which presumably can be regulated by local mechanisms. In chronic purulent wounds, the total proteolytic activity is significantly higher than that of postoperative wounds. At the same time, the antiproteolytic activity is significantly lower than the total proteolytic activity, and also lower than the antiproteolytic activity of postoperative wounds, which creates a pronounced imbalance between proteases and protease inhibitors and contributes to the chronicity of the inflammatory process in purulent wounds with the involvement of both local and systemic mechanisms of regulation.

Keywords:

:proteases, protease inhibitors, postoperative wounds, chronic purulent wounds, proteolytic activity, antiproteolytic activity.

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