EMERGING ROLE OF CIRCULATORY MICRORNAS AS BIOMARKER IN AUTISM

Prajila Mavila Research Scholar, Malwanchal University, Indore, Madhya Pradesh. Department of Health & Medical Sciences, Al Shaheen Paramedical College & Hospital, Mashrak 841417, Saran, Bihar, Email: prajilamavila@gmail.com
Mohammad Chand Jamali Program Leader, Dept of Health & Medical Sciences, Khawarizmi International College, 25669, Abu Dhabi, United Arab Emirates, Email: mjamali68@gmail.com

Abstract

A heterogeneous group of complex neurodevelopmental disorder is termed autism spectrum disorder (ASD) that is characterized by a change in behaviour, deficits of communications and social skills. The neurodevelopmental transcriptional networks of the human brain are mainly regulated through small non-coding RNAs and microRNAs. The emerging role of circulatory microRNAs has been proved in previous investigations and research that open new techniques for the treatment of human disease or disorder as prognostic biomarkers in Autism. The development of biomarkers is progressively considered as a cornerstone in the medical field that shows an effective role in the diagnosis of multiple diseases and helps effectively in discovering different drugs and limits the progress of multiple diseases. Biomarkers for autism spectrum disorder have not been established yet due to its complexities. Circulatory microRNAs in cell-free conditions are considered as next-generation biomarkers for multiple pathologies such as neurodevelopmental disorders and neurological disorders. The presence of cell-free microRNAs in bio fluids is noticed to be in extraordinary stable conditions and is non-invasive. This article is based on evaluating the emerging role of circulatory microRNAs as biomarkers in Autism disorder. Clinical aspects of Autism disorder, a brief introduction of microRNAs and their functions and role of microRNAs as a biomarker to detect Autism has been provided in the context of the paper.

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: Circulatory microRNAs, biomarkers, autism spectrum disorder, neurodevelopmental disorder, cell-free microRNAs.

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