STATE OF IMMUNE STATUS AND CYTOKINE PROFILE IN CHILDREN WITH CYSTIC FIBROSIS
Furkat Mukhitdinovich Shamsiev
Head of the Department of Pulmonology of the Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan
Xikmatbek Pirnazarovich Atajanov
Assistant of the Department of Pediatrics and Neonatology of the Urgench branch of the Tashkent Medical Academy, Urgench, Uzbekistan
Rano Anvarbekovna Musajanova
Senior researcher Department of Pulmonology of the Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan
Durumboy Musaevich Yakubov
Assistant of the Department of Propedeutics of Childhood Diseases of the Urgench branch of the Tashkent Medical Academy, Urgench, Uzbekistan
Bakhtiyor Gofurovich Bekchanov
Ph.D., Associate Professor, Head Department of Propedeutics of Childhood Diseases
Urgench branch of the Tashkent Medical Academy, Urgench, Uzbekistan
Abstract
Progressive lung pathology in children with cystic fibrosis is the cause of mortality in patients, despite the active use of various drugs that prolong their life, including mucolytic, antimicrobial therapy, and the emergence of pathogenetic targeted therapy.
The aim of the study was to study the immune status and profile of cytokines - IL-1β and IL-8 in cystic fibrosis in children. The data obtained allow us to conclude that significant changes in the immune system are determined in children with mixed form cystic fibrosis.
The study included 65 children with mixed cystic fibrosis aged 0 to 14 years. As a comparison group, 25 children with a recurrent course of obstructive bronchitis were examined. The control group consisted of 20 apparently healthy children of the same age.
In the group of children receiving basic therapy, the immunological parameters did not recover, within a year, in some cases, even decreased from the initial value. Studies have shown that through cytokine network failures and immune disorders, cystic fibrosis contributes to the aggravation of immunodeficiency and, possibly, the development or aggravation of the course of complications, which dictates the need for immunocorrective therapy.
Keywords:
:
children, cystic fibrosis, immunity, cytokines.
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