BIOCHEMICAL CHANGES IN CHILDREN WITH BRONCHOLUMINAL PATHOLOGY ON THE BACKGROUND OF A DIFFUSIVE EUTYREOID STATE
Forrukh Nodirzhanovich Mukhamedov
Applicant for the Department of Pulmonology of the Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan
Furkat Mukhitdinovich Shamsiev
Head of the Department of Pulmonology of the Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan
Rano Anvarbekovna Musajanova
Senior researcher Department of Pulmonology of the Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan
Nigora Davlyatovna Azizova
Senior researcher Department of Pulmonology of the Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan
Nargis Hayrullaevna Mirsalihova
Associate Professor of the Department of Childhood Diseases No. 1, Tashkent Medical Academy,
Tashkent, Uzbekistan
Nasiba Saidovna Agzamxodjaeva
Associate Professor of the Department of Childhood Diseases No. 1, Tashkent Medical Academy,
Tashkent, Uzbekistan
Abstract
The question of the relationship between the course of diseases of the thyroid gland and the bronchopulmonary system today remains an urgent problem of modern medicine. The influence of thyroid status on the course of bronchopulmonary pathology in children, depending on the age, severity and therapy of the disease, has been little studied. At the same time, insufficient attention to these pathophysiological mechanisms can lead to an increase in the severity of somatic pathology, a decrease in the functionality of the thyroid gland, frequent recurrence of the main pathological process, and reduce the effectiveness of therapy.
The aim of the study was to study the features of the biochemical parameters of bronchopulmonary pathology in children, occurring against the background of diffuse euthyroid goiter. The study of the state of the pituitary-thyroid system made it possible to establish the most pronounced changes in patients with bronchopulmonary pathology against the background of diffuse euthyroid goiter, indicating a decrease in the functional activity of the thyroid gland. In case of bronchopulmonary pathology against the background of diffuse euthyroid goiter, an increase in the membrane of lymphocytes of malondialdehyde and diene conjugates and a decrease in superoxide dismutase and catalase are determined, which leads to the destruction of membrane structures and disruption of their functioning.
Examined 120 children with bronchopulmonary pathology at the age from 7 to 14 years. Of these, 45 children - with recurrent bronchitis proceeding against the background of diffuse euthyroid goiter, 45 children - with community-acquired pneumonia of a protracted course, against the background of diffuse euthyroid goiter and 15 children with recurrent bronchitis without thyroid pathology and 15 patients with community-acquired pneumonia without thyroid pathology (comparison group).
Our studies show that in patients with bronchopulmonary pathology against the background of diffuse euthyroid goiter, hyperlipidemia, hypocholesterinemia, and an increase in the level of triglycerides, found by us, can serve as confirmation of a violation of the lipid spectrum of the blood serum of children.
Keywords:
:
protracted community-acquired pneumonia, recurrent bronchitis, thyroid gland, diffuse euthyroid goiter, biochemistry
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