Shazodakhon Saidbakiyevna Sultankhodjaeva
Republican specialized scientific and practical, Medical Center of Pediatrics of the Ministry of Health of the Republic of Uzbekistan, Center for the Development of Professional Qualifications of Pediatric Medical Workers of the Ministry of Health of the Republic of Uzbekistan
Tashkent, Uzbekistan
Inobat Muxamedjanovna Axmedova
Head of the Department of Pediatrics and Children's Nutrition, Center for the Development of Professional Qualifications of Pediatric Medical Workers of the Ministry of Health of the Republic of Uzbekistan, Tashkent, Uzbekistan
Abstract
The aim of the study was to study the features of the formation of the gastrointestinal form of food allergy in young children. There were 109 patients under observation, aged from 1 month to 3 years, who received treatment in the department of gastroenterology. All children underwent an immunological study to determine the lymphokine-producing ability of T-lymphocytes to allergens.
In this study, we wanted to determine the role of regulatory cells TGF-β1 and IL-10 in non-IgE associated forms of gastrointestinal food allergy in young children. Considering that, according to many authors, food protein-induced enterocolitis syndrome and allergic enteropathy are not attributed to IgE-associated forms of food allergy, it was important for us to evaluate the effect of TGF-β1 and IL-10 on the clinical manifestations of allergic enterocolitis in children.
The data obtained indicate that the cytokines of the TGF-β1 and IL-10 groups in gastrointestinal forms of food allergy act as regulators of inflammatory reactions. The regularities of the influence of the levels of transforming TGF-β1, IL-10 on the activation of the process in gastrointestinal forms of food allergy, more pronounced when the underlying disease is associated with increased IgE values, have been established.
Keywords:
:
Allergic enteropathy, TGF-β1, IL-10, gastrointestinal, IgE
References
References:
1. Zakharova I.N., Berezhnaya I.V. Food allergy in children: what is the reason for its growth? // Medical Council. 2018. No. 17. P. 156-162
2. Varlamov E.E., Pampura A.N., Okuneva T.S. Interrelation of the profile of sensitization to cow's milk proteins with the severity of clinical manifestations of atopic dermatitis and the presence of multiple food proteins intolerance in young children. Pediatrics. Journal named after G.N. Speransky 2018; (2): 36.
3. Borisova E.Yu., Lavrova AE, Tolkacheva NI, et al. Features of the cytokine profile in children with gastrointestinal tract pathology with food allergies at different age periods.// Cytokines and inflammation. 2015.Vol. 14.No. 1.P. 91-95Макарова С.Г., Галимова А.А.,
4. Fisenko A.P. et al. Markers of persistence of cow's milk protein allergy: results of a 5-year follow-up. //Pediatrics. Journal named after G.N. Speransky. 2020.Vol. 99. No. 2. S. 88-95
5. Dementyeva EA, Gurina OP, Blinov AE, et al. Study of the subpopulation composition of lymphocytes in atopic dermatitis in children // Materials of the IX scientific-practical conference "Vorontsov readings". St. Petersburg, 2016.S. 53-54
6. Davletova Z. Zh. Clinical features of food allergy in young children, depending on the type of feeding. Abstract for the degree of candidate of medical sciences. Tashkent, 2007.S. 85
7. Kamilova A.T., Geller S.I., Mirzamukhamedov D.M. The syndrome of enterocolitis induced by food proteins in young children: a description of 18 cases. // Questions of Pediatric Dietetics. 2015.Vol. 13.No. 4.P. 56-62Evasovic J.M., Singer CA. Regulation of IL-17A and implications for TGF-31 comodulation of airway smooth muscle remodeling in severe asthma. Am J Physiol Lung Cell Mol Physiol. 2019; 316(5): L843-L868.
8. Flom J.D., Sicherer S.H. Epidemiology of cow's milk allergy. Nutrients 2019;11(5):1051. DOI: 10.3390/nu11051051.
9. Scott H. Sicherer, MD, and Hugh A. Sampson, MDFood allergy: Epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol 2014;133:291-307.
10. Ginkel C.D., van der Meulen GN, Bak E et al. Retrospective observational cohort study regarding the effect of breastfeeding on challenge-proven food allergy.// Eur J Clin Nutr.‒ 2018 Feb 19.
11. Meyer R., Chebar Lozinsky A., Fleischer D.M. et al. Diagnosis and management of non-IgE gastrointestinal allergies in breastfed infants-An EAACI Position Paper. Allergy 2020;75(1):14–32.
12. Meyer R. Nutritional disorders resulting from food allergy in children. Pediatr Allergy Immunol. 2018;29(7):689–704. doi: 10.1111/ pai.1296
13. Pensabene L., Salvatore S, D’Auria E, Parisi F.1, Concolino D , Borrelli O, Thapar N, Staiano A,Vandenplas Y,Saps M. Cow’s Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children? //Nutrients 2018, 10, 1716; doi:10.3390/nu10111716
14. Vandenplas Yvan, Zakiudin Munasir, Badriul Hegar, Dewi Kumarawati, Ahmad Suryawan, Muzal Kadim, Julistio Tb Djais, Ray Wagiu Basrowi, Deni Krisnamurti, A perspective on partially hydrolyzed protein infant formula in nonexclusively breastfed infants // Korean J Pediatr. 2019; 62 (5): 149-154.
15. Benlounes N., Candalh C., Matarazzo P., et al. The time-course of milk antigen-induced TNF-alpha secretion differs according to the clinical symptoms in children with cow’s milk allergy. J Allergy Clin Immunol 1999; 104:863
