Tadjieva N.U.
Republican Specialized Scientific and Practical Medical Center for Epidemiology, Microbiology, Infectious and Parasitic Diseases, Uzbekistan
Abstract
Objective: to study of antimicrobial susceptibility of S.pneumoniae isolated from nasopharyngeal swabs of adult patients with acute respiratory infections.
Material and methods: a bacteriological study was carried out on 240 samples of nasopharyngeal mucus taken from patients with a diagnosis of "Acute respiratory infection" aged 18 years and older who were inpatient treatment at the City Clinical Infectious Diseases Hospital No. 1 in Tashkent (CCIDH No. 1). Determination of sensitivity to antimicrobial drugs was carried out by the disk-diffusion method and the E-test method. The data were interpreted according to the recommendations of the European Committee of antimicrobial susceptibility test (EUCAST).
Results and discussion: from all examined 240/100% of patients with acute respiratory infections of the upper and lower respiratory tract, S. pneumoniae was isolated from nasopharyngeal mucus in 56 / 23.3% of patients. The most significant factors in maintaining the carriage of S. pneumoniae were such factors as chronic diseases of the ENT organs, unsatisfactory living conditions, and bad habits. The obtained isolates of S. pneumoniae in 73.3% of cases retained sensitivity to penicillin, in 26.7% of the strains were resistant. Also, resistant strains were detected in 25.8% of isolates to azithromycin and in 27.3% to erythromycin.
Conclusions: In patients with ARI, from whose nasopharyngeal mucus S. pneumoniae was isolated, 66.1% of cases had chronic diseases of the ENT organs (chronic tonsillitis, chronic sinusitis / sinusitis). The isolated pneumococcal strains showed resistance to penicillins and macrolides. In risk groups for chronic respiratory diseases, vaccination with pneumococcal conjugate vaccine (PCV-13) is recommended.
Keywords:
:
pneumococci, nasopharyngeal carriage, antibiotic sensitivity.
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