DEVELOPMENT OF A METHOD FOR QUANTITATIVE DETERMINATION OF TRITERPENE SAPONINS IN THE GRASS OF THE TURKESTAN DESERT

Abdullabekova Nargiza Abduvakhidovna1, Sultanova Adolat Aminbaevna1, Urinbaeva Inobat Rakhimboy Kizi1, Abdukarimova Halima Abdumannon Kizi1 1Tashkent Pharmaceutical Institute

Abstract

An analysis of the current state of research in the field of studying the representatives of the family of lucidaceae - (Lami-aceae) showed that they have a wide spectrum of biological activity and are used both in scientific and folk medicine. These representatives include species of the genus Leonurns L. In many species of this genus, various groups of biologically active substances have been found: flavonoids (rutin, genquanin, quercetin), tannins, saponins, nitrogen-containing compounds (leonurin, stachydrin). Different species of the genus motherwort are official and are included in the National Pharmacopoeias of many countries of the world. Different species of the genus motherwort are official and are included in the National Pharmacopoeias of many countries of the world. The State Pharmacopoeia of the XI edition includes motherwort and five-lobed motherwort, known for their pronounced sedative effect (2-3 times stronger than that of valerian tincture). Pharmacological studies carried out abroad have also revealed hormone-like, antitumor, antimicrobial, anti-inflammatory and antioxidant effects of motherwort. To achieve this goal, it was necessary to solve the following tasks: - to study the current state of research in the field of studying terpenoid-containing plants used in domestic medical practice and drugs developed on their basis; - to investigate the terpenoid composition of Turkestan motherwort herb; - to propose methods of qualitative and quantitative analysis of terpenoid compounds of Turkestan motherwort raw materials.

Keywords:

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: triterpene glycosides, (triterpene saponins), potentiometric method, oleanolic acid, gravimetric method, UV spectrum, Fisher's criterion, Turkestan motherwort herb.


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