DEVELOPMENT OF DERMATOLOGICAL MEDICINAL FILMS TECHNOLOGY OF COMPLEX ACTION
Tureeva Galiya Matnazarovna
Candidate of Pharmaceutical Sciences, Associate Professor; Tashkent Pharmaceutical Institute, Department of Medicinal Forms Technology. E-mail: info@pharmi.uz
Ishmukhamedova Muattar Alavuddinovna
Candidate of Pharmaceutical Sciences, Assistant of Department of Medicines Industrial Technology, Tashkent Pharmaceutical Institute, E-mail: info@pharmi.uz
Nigmatjonov Abdurashid Sagdulla ugli
Assistant of Department of Medical Radiology, Tashkent Medical Academy, E-mail: info@pharmi.uz
Sadykova Nargiza Baxtiyarovna
Assistant of Department of Information Technology and Mathematics, Tashkent Pharmaceutical Institute; E-mail: info@pharmi.uz
Rakhimova Gulnora Rakhim qizi
Candidate of Pharmaceutical Sciences, Associate Professor of Department of Medicines Industrial Technology, Tashkent Pharmaceutical Institute. E-mail: info@pharmi.uz
Abstract
The article presents the results of research on the development of the optimal composition and technology of dermatological films of complex action, including those containing methyluracil, which stimulates regenerative processes, the antibacterial substance chloramphenicol, and chlorhexidine, which has an antiseptic effect. The nature of the interaction that occurs in the studied films between medicinal substances and a solution of the film-forming polymer Na-CMC has been studied. Using microbiological methods, the antibacterial activity of the recommended films was studied and it was found that they exhibit pronounced antimicrobial activity against: St. aureus, E. coli, Ps. aeruginosa, C. Albicans. Methods have been developed for the quantitative determination of the active substances of films of complex action by the method of high-performance liquid chromatography.
Keywords:
dermatological polymer films, methyluracil, chlorhexidine, chloramphenicol, film-forming polymer Na-CMC.Full Text:
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