INFLUENCE OF A NEW AMINO ACID BLOOD SUBSTITUTE ON THE COURSE OF INTOXICATION CAUSED BY HELIOTRIN IN EXPERIMENT

Larisa I. Shevchenko Candidate of biological sciences (PhD), Head of the grant project, "Department of Molecular Medicine and Cellular Technologies", Republican Specialized Scientific and Practical Medical Center of Hematology (RSNPMTsG), MoH of RUz, Bunedkor str. 42А, Chilanzar distr., Uzbekistan, Tashkent, 100097. E-mail: moriturus1958@mail.ru
Hamid Y. Karimov Doctor of Medical Sciences (DSc), Professor, Head of the Department of Molecular Medicine and Cellular Technologies, Republican Specialized Scientific and Practical Medical Center of Hematology (RSNPMCG), Tashkent Pediatric Medical Institute, MoH of RUz, Bagishamal str., 223, Yunusabad region, Tashkent, Uzbekistan, 100140. E-mail: info.niigem@minzdrav.uz
Zukhra A. Sayfutdinova Applicant, Republican Specialized Scientific and Practical Medical Center of Hematology (RSNPMCG), Republican Specialized Scientific and Practical Medical Center of Hematology (RSNPMTsG), MoH of RUz, Bunedkor str. 42А, Chilanzar distr., Uzbekistan, Tashkent, 100097. E-mail: zuxra.sayfutdinova.91@bk.ru
Timur R. Alimov Candidate of Medical Sciences (PhD), Hematologist, Senior Researcher of the Grant Project, Republican Specialized Scientific and Practical Medical Center of Hematology (RSNPMCG), Republican Specialized Scientific and Practical Medical Center of Hematology (RSNPMTsG), MoH of RUz, Bunedkor str. 42А, Chilanzar distr., Uzbekistan, Tashkent, 100097. E-mail: altirar@mail.ru
Meri G. Lipartiya Candidate of Medical Sciences (PhD), Pediatrician, Assistant of the Department of Propedeutics of Childhood Diseases and Hematology of the Tashkent Pediatric Medical Institute (TashPMI), Oncologist at Pediatric Oncology Department, Chemotherapy Department, Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology (RSNPMTSOiR) MoH of RUz, Bunedkor str. 42А, Chilanzar distr., Uzbekistan, Tashkent, 100097. E-mail: lipartiya_lena@mail.ru

Abstract

The work aimed to study the effect of a new amino acid blood substitute during heliotrine intoxication. Experimental studies were performed on 60 rats weighing 180-220g. on a model of heliotrine intoxication in comparison with the drug "Infezol-40". We studied: biochemical parameters, indicators of "endogenous intoxication" (EI), lipid peroxidation (LP), the activity of enzymes of the antioxidant system (AOS), and general antioxidant status. The study results showed that the "new amino acid infusion drug" had a good detoxification effect that reduces endogenous intoxication indicators and restores the biochemical parameters of the liver's functional and metabolic parameters during heliotrin intoxication. The use of a "new amino acid infusion drug" for heliotrin intoxication reduced the activity of hyperlipoperoxidation processes and restored the activity of AOS enzymes, antioxidant status, showing a more pronounced antioxidant effect compared to the drug "Infezol-40."

Keywords:

"New amino acid infusion drug", Amino acids, Heliotrin intoxication, Lipid peroxidation, Antioxidant system, General antioxidant status.


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