COMPARATIVE STUDY OF NEW MEDIСINE IN THE FORM OF 10% OINTMENT WITH PSILOSIS-BALSAM FOR THE ALLERGIC CONTACT DERMATITIS OF GUINEA PIG

Khatamov Khayrulla PhD, MD, Department of Immunopharmacology, Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan. Email: doctorhatamov@mail.ru
Suyarov Akram DSc, MD, Head of the Department of Immunopharmacology, Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan.
Mutalov Boburjon Scientific Researcher, MD, Department of Immunopharmacology, Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan.
Abdashimov Zafar Scientific Researcher, PhD, MD, Tashkent State Dental Institute. Department of Public health, health management and physical education.
Nurmamatova Kurbonoy Scientific Researcher, MD, Tashkent State Dental Institute. Department of Public health, health management and physical education.

Abstract

The ointment has been prepared on hydrophobic basis from local raw materials. Allergic contact dermatitis was caused by double application of 5% alcohol-acetone 2,4-dinitrochlorobenzene on guinea pigs according to E.Y. Ivleva and P.M. Zalkan (1965). The experimental animals were divided into 3 groups of 10 animals each. Changes in the skin integument were observed on days 1, 3, 5, 7, 9 and 11 of treatment after the last application of the allergen. The severity of inflammatory manifestations of the skin was assessed in points according to I.V. Kutuzov (1996), and the thickness of the skin fold with a micrometer. In a comparative study of the results of treatment of allergic contact dermatitis, it was found that the use of a new combined 10% hydrophobic ointment of a thick extract of a bur-marigold of tripartite and dry extract of licorice root is more effective in the treatment of contact allergic dermatitis than the antihistamine psilosis-balsam. Ключевые слова: allergic contact dermatitis, 2,4-dinitrochlorobenzene, guinea pig, 10% combined ointment, thick extract of bur-marigold, dry extract of licorice root, psilosis-balsam.

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