EVALUATION OF GASTROPROTECTIVE AND REGENERATIVE PROPERTIES OF FLAVONOIDS ISOLATED FROM BUDS OF SAPHORA JAPONICA IN COLLAGEN.

Natalia E. Tseomashko MD, PhD, Head of the Department of Medical and Genetic Research of the Interuniversity Research Laboratory of the Tashkent Medical Academy of the Ministry of Health of the Republic of Uzbekistan. Tashkent, Uzbekistan e-mail: tsne_77@list.ru
Aziza D. Abidova Junior Researcher, Interuniversity Research Laboratory of the Tashkent Medical Academy of the Ministry of Health of the Republic of Uzbekistan. Tashkent, Uzbekistan e-mail: info@tma.uz
Sardor D.Makhmudov Basic doctoral student of the Institute of Bioorganic Chemistry of the Academy of Sciences of the Republic of Uzbekistan. Tashkent, Uzbekistan e-mail: info@tma.uz
Rakhmanov A.Kh MD, Professor assistant, Tashkent Medical Academy, Tashkent, Uzbekistan e-mail: info@tma.uz

Abstract

Wound dressings membranes based on rat collagen with the addition of the flavonoid quercetin (RC-Qu) and rutin (RC-Ru) are effective in the treatment of purulent wounds of the skin, since in experimental models of purulent wounds these wound dressings reduce the epithelialization time of purulent wounds by 11.1 12.2 days and 8.4-9.2 days, respectively, compared to control wounds that were not treated with anything (the wounds were completely epithelized on 28.9 ± 0.6 days), which is due to the antioxidant properties of quercetin and rutin. In addition, it has been experimentally proven that gel compositions RC-Qu and RC-Ru have gastroprotective and antiulcer properties.

Keywords:

flavonoid, quercetin, rutin, antiulcer activity


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