Abstract
Acetylcholine Esterase (AChE) hydrolyses the neurotransmitter acetylcholine (Ach) to acetate and choline promoting the termination of signals from nerve cells to muscle cells. A comprehensive investigation of Acetylcholine Esterase (AChE) activity, aimed to elucidate the potential health benefits derived from selected Indian herbal medicinal plants. A comparative analysis of AChE activity levels and isolation and characterization of a potent AChE inhibitor from this native plant source was envisaged. Furthermore, it delves into the application and implications of this inhibitor for human health. The first phase of the Initial study involved measuring quantifying AChE activity in various biological samples, including tissues and serum, using the most advanced biochemical assays. By analyzing a diverse set of specimens, the study aimed to establish a basic understanding of AChE activity in different physiological contexts, thereby providing valuable insight into the importance of AChE. its importance to human health. The study then focused on the isolation and purification of a novel AChE inhibitor from a selected Indian medicinal plant. Using advanced chromatographic techniques and spectroscopic analysis, the study elucidated the chemical structure and functional properties of the isolated compound. Elucidation of the chemical structure and functional properties of the isolated product was done using advanced chromatographic techniques and spectroscopic analysis. Exploration of practical applications of AChE inhibitors in the field of human health was attempted by studying the effects of inhibitors on the regulation of neurotransmitters, synaptic function, and cognitive processes. Besides, current research on the evaluation of the possibility of using inhibitors in the treatment of neuro-degenerative disorders, such as Alzheimer's disease, in which dysregulation of AChE is a prominent feature is been done. In summary, this study provides a multidimensional view study of AChE activity and its modulation via inhibitor obtained from Indian medicinal plants is presented here. The study By providing comparative analysis, chemical characterization and insights into its application to human health , this study contributes significantly to our the deeper understanding of the potential benefits. of this study. of natural compounds derived from native flora. Ultimately, this opens up new avenues for the development of novel therapeutic interventions targeting AChE-related health problems.
Keywords:
:Acetylcholin Esterase, enzyme activity, inhibitors, neuro-degenerative disorders, drug development, therapeutic applications.
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