Raghdan H. Mohsin1,Risala H Allami2, Dhurgham I. Al Alnabi3
Raghad S. Mouhamad4, Enas Ali Tarkan1
Abstract
Obesity is a leading preventable cause of death worldwide, with increasing prevalence in adults and children, Obesity is one of the most important health problems in human beings and it increases the likelihood of various diseases, such as type 2 diabetes, and particularly heart disease, systemic hypertension, hyperlipidemia, cardiovascular diseases, and certain types of cancer and osteoarthritis and authorities view it as one of the most serious public health challenges of the 21st century. The consumption of bioactive compounds from the diet or dietary supplementation is one possible way to control obesity and to prevent or reduce the risks of getting various obesity-related diseases. Recently, there has been a remarkable interest in finding natural lipid inhibitors from natural products to replace synthetic compounds. Natural substances are presumed to be safe since they occur in plant foods, and are therefore seen as more desirable than their synthetic counterparts. Quinoa (Chenopodium quinoa) is plant that recently has been successfully grown in Iraq, providing seeds rich in nutrients and bioactive compounds. The popularity of its seeds has increased in recent years due to the claims of health benefits and super food qualities. This was a dose-response randomized, controlled, single-blind trial with a parallel design (1 control and 2 treatment groups) that compared the effect of 50 and 100 g quinoa/d in 50 overweight and obese women over a 12-wk intervention period. Body composition, and total, LDL, and HDL cholesterol were not significantly altered by quinoa consumption (P > 0.05). Mean serum triglyceride (TG) concentration was reduced significantly in the 100-g quinoa group from 1.38 to 0.85 mmol/L and in the 50-g quinoa group from 1.25 to 1.02 mmol/L at12 wk (P< 0.05). No significant changes in TGs were observed in the control groups.
Keywords:
:heart disease, systemic hypertension, hyperlipidemia, cardiovascular disease
References
1. Chan, R. S., & Woo, J. (2010). Prevention of overweight and obesity: how effective is the current public health approach. International journal of environmental research and public health, 7(3), 765–783. https://doi.org/10.3390/ijerph7030765
2. Txakartegi Etxebarria X, López Mateo M, Aurrekoetxea JJ. Obesidad y sobrepeso. Aproximación a la efectividad de una intervención sanitaria [Obesity and overweight. An assessment of the effectiveness of a public health intervention]. An Pediatr (Barc). 2014 Jun;80(6):379-86. Spanish. doi: 10.1016/j.anpedi.2013.08.008. Epub 2013 Oct 16. PMID: 24139561.
3. Hruby, A., & Hu, F. B. (2015). The Epidemiology of Obesity: A Big Picture. PharmacoEconomics, 33(7), 673–689. https://doi.org/10.1007/s40273-014-0243-x
4. Bosu WK. An overview of the nutrition transition in West Africa: implications for non-communicable diseases. Proc Nutr Soc. 2015 Nov;74(4):466-77. doi: 10.1017/S0029665114001669. Epub 2014 Dec 22. PMID: 25529539.
5. World Health Organization (WHO). Global Status Report on noncommunicable diseases 2014. Geneva: WHO; 2014.
6. Oliveira, A., Araújo, J., Severo, M. et al. Prevalence of general and abdominal obesity in Portugal: comprehensive results from the National Food, nutrition and physical activity survey 2015–2016. BMC Public Health 18, 614 (2018). https://doi.org/10.1186/s12889-018-5480-z
7. World Health Organization. (2014). Global status report on noncommunicable diseases 2014. World Health Organization. https://apps.who.int/iris/handle/10665/148114
8. Saha, A., & Alleyne, G. (2018). Recognizing noncommunicable diseases as a global health security threat. Bulletin of the World Health Organization, 96(11), 792–793. https://doi.org/10.2471/BLT.17.205732
9. Hatefi A, Allen LN, Bollyky TJ, Roache SA, Nugent R. Global susceptibility and response to noncommunicable diseases. Bull World Health Organ. 2018 Aug 1;96(8):586-588. doi: 10.2471/BLT.17.206763. Epub 2018 Jun 12. PMID: 30104800; PMCID: PMC6083392.
10. Hasahya, O. T., Berggren, V., Sematimba, D., Nabirye, R. C., & Kumakech, E. (2016). Beliefs, perceptions and health-seeking behaviours in relation to cervical cancer: a qualitative study among women in Uganda following completion of an HPV vaccination campaign. Global Health Action, 9(29336), 1–9. Retrieved from https://doi.org/10.3402/gha.v9.29336
11. Dai, H., Alsalhe, T. A., Chalghaf, N., Riccò, M., Bragazzi, N. L., & Wu, J. (2020). The global burden of disease attributable to high body mass index in 195 countries and territories, 1990-2017: An analysis of the Global Burden of Disease Study. PLoS medicine, 17(7), e1003198. https://doi.org/10.1371/journal.pmed.1003198
12. GBD 2017 Risk Factor Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018 Nov 10;392(10159):1923-1994. doi: 10.1016/S0140-6736(18)32225-6. Epub 2018 Nov 8. Erratum in: Lancet. 2019 Jan 12;393(10167):132. Erratum in: Lancet. 2019 Jun 22;393(10190):e44. PMID: 30496105; PMCID: PMC6227755.
13. Deng Y, Zhao P, Zhou L, Xiang D, Hu J, Liu Y, Ruan J, Ye X, Zheng Y, Yao J, Zhai Z, Wang S, Yang S, Wu Y, Li N, Xu P, Zhang D, Kang H, Lyu J, Dai Z. Epidemiological trends of tracheal, bronchus, and lung cancer at the global, regional, and national levels: a population-based study. J Hematol Oncol. 2020 Jul 20;13(1):98. doi: 10.1186/s13045-020-00915-0. PMID: 32690044; PMCID: PMC7370495.
14. Hill A. J. (2017). Obesity in Children and the 'Myth of Psychological Maladjustment': Self-Esteem in the Spotlight. Current obesity reports, 6(1), 63–70. https://doi.org/10.1007/s13679-017-0246-y
15. Lee K, Guy A, Dale J, Wolke D. Does psychological functioning mediate the relationship between bullying involvement and weight loss preoccupation in adolescents? A two-stage cross-sectional study. Int J Behav Nutr Phys Act. 2017 Mar 24;14(1):38. doi: 10.1186/s12966-017-0491-1. PMID: 28340581; PMCID: PMC5364676.
16. Navarro-Perez, D., Radcliffe, J., Tierney, A., & Jois, M. (2017). Quinoa Seed Lowers Serum Triglycerides in Overweight and Obese Subjects: A Dose-Response Randomized Controlled Clinical Trial. Current developments in nutrition, 1(9), e001321. https://doi.org/10.3945/cdn.117.001321
17. Kaur, K. D., Jha, A., Sabikhi, L., & Singh, A. K. (2014). Significance of coarse cereals in health and nutrition: a review. Journal of food science and technology, 51(8), 1429–1441. https://doi.org/10.1007/s13197-011-0612-9
18. Awika JM, Rooney LW. Sorghum phytochemicals and their potential impact on human health. Phytochemistry. 2004 May;65(9):1199-221. doi: 10.1016/j.phytochem.2004.04.001. PMID: 15184005.
19. Mukai Yuuka *, Kataoka Saori and Sato Shin , Sorghum (Sorghum bicolor) Extract Affects Plasma Lipid Metabolism and Hepatic Macrophage Infiltration in Diabetic Rats, Current Nutrition & Food Science 2020; 16(5) . https://dx.doi.org/10.2174/1573401315666190114153933
20. Vergara, M.; Hauser, M.E.; Aronica, L.; Rigdon, J.; Fielding-Singh, P.; Shih, C.W.; Gardner, C.D. Associations of Changes in Blood Lipid Concentrations with Changes in Dietary Cholesterol Intake in the Context of a Healthy Low-Carbohydrate Weight Loss Diet: A Secondary Analysis of the DIETFITS Trial. Nutrients 2021, 13, 1935. https://doi.org/10.3390/nu13061935
21. Takao T, Nakamichi W, Kana Y, Syoko I, Saori S, Yukari T, Kenichi N, Yotaro K. Hypocholesterolemic effect of protein isolated from quinoa (Chenopodium quinoa Willd.) seeds. Food Sci Technol Res 2005;11:161–7.
22. Foucault AS, Even P, Lafont R, Dioh W, Veillet S, Tome D, Huneau JF, Hermier D, Quignard-Boulange A. Quinoa extract enriched in 20-hydroxyecdysone affects energy homeostasis and intestinal fat absorption in mice fed a high-fat diet. Physiol Behav 2014;128:226–31.
23. Rojas W, Pinto M. 2015. Chapter 8: Ex situ conservation of quinoa: the bolivian experience. In: Murphy KM, Matanguihan J, editors. Quinoa: Improvement and Sustainable Production. Hoboken, NJ: John Wiley & Sons, Inc. p 128-30.
24. Simnadis TG, Tapsell LC, Beck EJ. 2015. Physiological Effects Associated with Quinoa Consumption and Implications for Research Involving Humans: a Review. Plant Foods Hum Nutr 70(3), 238-49.
